![]() Sensory stimulations were applied in 28 fMRI sessions during interictal and ictal periods, as assessed by concurrent EEG recordings, and whole brain responsiveness and hemodynamic responses were compared between these two states. Animals were imaged continuously using a quiet zero-echo-time functional magnetic resonance imaging (fMRI) sequence while in a non-curarized awake state, allowing for naturally occurring seizures to be produced inside the 9.4T magnet. This study aimed to investigate whole-brain responsiveness to visual and somatosensory whisker stimulation in GAERS, a well-established rat model for absence epilepsy. The mechanism underlying the reduced responsiveness to external stimulus remains unknown. In patients suffering absence epilepsy, recurring seizures can significantly decrease their quality of life and lead to yet untreatable comorbidities. ![]() Absence seizures are characterized by regular and generalized spike-and-wave electrical patterns in the brain, resulting in unresponsiveness to environmental stimuli.
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